Publications

Peer-Reviews

2015-Present
  • Habchi KM,  Ashikhmina E, Montiero Vieira V, Shahram JT, Isselbacher EM, Sundt III TM, Shekar P, Muehlschlegel JD, Bicuspid Aortic Valve Consortium, Body S. Association between bicuspid aortic valve morphotype and regional dilatation of the aortic root and trunk. Int J Cardiovasc Imaging, DOI 10.1007/s10554-016-1016-8
  • Appari M, Breitbart A, Brandes F, Szaroszyk M, Froese N, Korf-Klingebiel M, Mohammadi MM, Grund A, Scharf G, Wang H, Zwadlo C, Fraccarollo D, Schrameck U, Nemer M, Wong W, Olson E, Katus H, Wollert K, Müller O, Bauersachs J, Heineke J. C1q-TNF-related protein-9 promotes cardiac hypertrophy and failure by activating ERK5. Circulation Research. 2016;CIRCRESAHA.116.309398
  • Jurado Acosta A, Rysa J,Szabo Z, Moilanen A-M, Komati H, Nemer M, Ruskoaho H. Transcription factor PEX1 modulates extracellular matrix turnover through regulation of MMP-9 expression, Cell & Tissue Research, Epub Nov 8 2016, DOI:10.1007/s00441-016-2527-2
  • Mathieu S, El Khoury N, Rivard K, Gelinas R, Goyette P, Paradis P, Nemer M, Fiset C. Reduction in Na+ current by Angiotensin II is Mediated by PKCα in Mouse and Human Induced Pluripotent Stem Cells Derived Cardiomyocytes. Heart Rhythm Society, Vol 13, Issue 6, pp 1346-1354, June 2016
  • Kassab K, Hariri H, Aki F, Manal Z, El-Rassy I, Gharibeh L, Nemer M, Bita F, Nemer G. GATA5 mutation homozygosity linked to a double outlet right ventricle phenotype in a Lebanese patient. Mol Genet Genomic Med, Dec 2015, doi: 10.1002/mgg3.190
  • Kinnunen S, Valimaki M, Tolli M, Wohlfahrt G, Darwich R, Komati H, Nemer M, Ruskoaho. Nuclear receptor-like structure and interaction of congenital heart disease-associated factors  GATA4-NKX2.5. PLOS ONE. December 7, 2015. Vol 10, Issue 12
  • Messaoudi S, He Y, Gutsol A, Hébert R, Vilmundarson R, Chalmers J, Hamet P, Tremblay J, McPherson R, Stewart Alexandre FR, Touyz RM, Nemer M, Endothelial Gata5 transcription factor regulates blood pressure, Nature Communications,November 30, 2015, DOI: 10.1038/ncomms9835
  • Hiba Komati and Mona Nemer: Repairing hearts with AKT. PNAS 2015 ; published ahead of print October 19, 2015, doi:10.1073/pnas.1517489112
  • Maharsy W, Nemer M. Chemotherapy Induced Cardiotoxicity: Facts, Breakthroughs, and Challenges, UOttawa Journal of Medicine, Volume 5, Issue II, 2015/05
  • Nemer M, Gharibeh L, Guiding Cardiac Conduction with GATA, Circulation Cardiovascular Genetics, 2015; 8: 247-249doi: 10.1161/CIRCGENETICS.115.001039
  • Mathieu P, Bossé Y, Huggins G, Della Corte A, Pibarot P, Michelena H, Limongelli G, Boulanger M-C, Evangelista A, Bedard E, Citro R, Body B, Nemer M, Schoen F. Pathology and Pathobiology of bicuspid aortic valve: state of the art and novel research perspective. J Path: Clin Res 2015, Published online April 2015. DOI: 10.1002/cjp2.21
  • Yamak A, Georges R, Sheikh-Hassani M, Morin M, Komati H, Nemer M. Novel exons in the Tbx5 gene locus generate protein isoforms with distinct expression domains and function, J Biol Chem, Vol. 290, No. 11, pp. 6844–6856 Epub January 2015
2010-2014
  • Gharibeh L, Nemer M. The hereditary basis of biscupid aortic valve disease: a role for screening? Advances in Genomics and Genetics, 2015-5, p11-17, December 2014
  • Aries A, Whitcomb J, Shao W, Komati H, Saleh M, Nemer M., Caspase-1 cleavage of transcription factor GATA4 and regulation of cardiac cell fate, Cell Death Dis, epub Dec 2014, 11;5:e1566. doi: 10.1038/cddis.2014.524
  • Straubinger J, Schöttle V, Bork N, Subramanian H, Schönberger T, Gawaz M, Nemer M, Lukowski R. Sildenafil does not prevent cardiomyocyte AT1R signaling induced heart hypertrophy and fibrosis, J Pharmacol Exp Ther, published ahead of print July 8, 2015, doi:10.1124/jpet.115.226092
  • Gallagher J, Yamak A, Kirilenko P, Black S, Bochtler M, Lefebvre C, Nemer M, Latinkic B. Carboxy terminus of GATA4 transcription factor is required for its cardiogenic activity and interaction with CDK4, Mech Dev, Nov 2014, 134:31-41 Epub September 21 2014
  • Ma CX, Song YL, Xiao L, Xue LX, Le WJ, Laforest B, Komati H, Wang WP, Jia ZQ, Zhou CY, Zou Y, Nemer M, Zhang SF, Bai X, Wu H, Zang MX, EGF is required for cardiac differentiation of P19CL6 cells through interaction with GATA-4 in a time- and dose-dependent, Cell Mol Life Sci, 2015, 72:2005–2022, epub Dec 14 2014,DOI 10.1007/s00018-014-1795-9; PMID: 25504289
  • Mailloux R, Xuan JY, McBride S, Maharsy W, Thorn S, Holterman CE, Kennedy C, Rippstein P, deKemp R, daSilva J, Nemer M, Lou MF, Harper ME. Glutaredoxin-2 is required to control oxidative phosphorylation in cardiac muscle by mediating deglutathionylation reactions, J Biol Chem, May 2014 23;289(21):14812-28, epub April 12, 2014
  • Yamak A, Latinkic B, Dali R, Temsah R, Nemer M., Cyclin D2 is a GATA4 Cofactor in Cardiogenesis, Proc Natl Acad Sci, 111(4); 1415-1420, January 2014.
  • Maharsy W, Aries A, Mansour O, Komati H, Nemer M., Aging is a risk factor in Imatinib mesylate cardiotoxicity, European Journal of Heart Fail. 2014 Apr;16(4):367-76.
  • Hitz MP, Lemieux-Perreault LP, Marshall C, Feroz-Zada Y, Davies R, Yang SW, Lionel AC, D’Amours G, Lemyre E, Cullum R, Bigras JL, Thibeault M, Chetaille P, Montpetit A, Khariy P, Overduin B, Klaassen S, Hoodless P, Nemer M, Stewart AFR, Boerkoel C, Scherer SW, Richter A, Dubé MP, Andelfinger G. Rare copy number variants contribute to congenital left-sided heart disease, PLoS Genet 8(9): September 2012.
  • Laforest B, Nemer M. Genetic insights into bicuspid aortic valve formation. Cardiology Research and Practice. Volume 2012, Article ID 180297.
  • Yamak A., Temsah R., Maharsy W., Caron S., Paradis P., Aries A., Nemer M. Cyclin D2 rescues size and function of GATA4 haploinsufficient hearts, Am J Physiol Heart Circ Physiol. 2012 Oct 15; 303(8):H1057-66. Epub 2012 Aug 24.
  • Yasuda N, Akazawa H, Ito K, Shimizu I, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito A, Oka T, Shiojima I, Tamura K, Umemura S, Nemer M, Komuro I. Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice, Hypertension, 2012, 59(3):627-633
  • Gallagher J., Komati H, Roy E, Nemer M, Latinkic B. Dissociation of cardiogenic and post-natal myocardial activities of GATA4, Mol Cell Biol, 2012, 32 (12):2214
  • Laforest B, Nemer M. A Hand for the epicardium, Circulation Research. April 2011, 108(8):900-902
  • Rivard K, Grandy S, Douillette A, Paradis P, Nemer M, Allen B, Fiset C. Overexpression of type 1 angiotensin II receptors impairs excitation-contraction coupling in the mouse heart. AM J PHYSIOL-HEART C, April 2011, 301(5):H2018-H2027
  • Hariri F, Nemer G, Nemer M. T-box factors: insights into the evolutionary emergence of the complex heart, Ann. Med., 2012 Nov;44(7):680-93 (Epub 2011 Sep 19).
  • Dubé MP, Bigras JL, Thibeault M, Bureau N, Chetaille P, Richter A, Mercier J, Bellavance M, Rohlicek C, Rozen R, Nemer M, Khairy P, Gendron R, Andelfinger G. Design and rationale of a genetic cohort study on congenital heart disease: experiences from a multi-institutional platform in Québec, Cardiol Young. 2011 Dec;21(6):654-64. Epub 2011 Jul 4
  • Laforest B, Nemer M. GATA5 interacts with GATA4 and GATA6 in outflow tract development. Dev Biol. 2011 October 15, Vol 358, Issue 2, Pages 368-378
  • Laforest B, Andelfinger G, Nemer M. Loss of GATA5 in mice leads to bicuspid aortic valve, J Clin Invest, 2011;121(7):2876–2887.
  • Komati H, Maharsy W, Beauregard J, Hayek S, Nemer M. ZFP260 an inducer of cardiac hypertrophy and a nuclear mediator of endothelin-1 signaling. J Biol Chem, 2011, 286(2):1508-16. Epub 2010 Nov 4
  • Rysa J, Tenhunen O, Serpi R, Pennanen H, Soini Y, Nemer M, Leskinen H, Ruskoaho H. GATA-4 is an angiogenic survival factor of the infarcted heart, Circulation: Heart Failure. 2010 May 1;3 (3):440-50. Epub 2010 Mar 3.
  • Nemer G, Nemer M. Tbx5 et l’adaptation du cœur à la vie sur terre. Med Sci (Paris). 2010 Aug-Sep;26(8-9):699-700
  • Nadeau M, Georges RO, Laforest B, Lefebvre C, Paradis P, Bruneau BG, Andelfinger G, Nemer M.  An endocardial pathway involving Tbx5, Gata4 and Nos3 required for atrial septum formation. Proc Natl Acad Sci USA. 2010;107(45):19356-61.Nature 2008 – condCond
  • Hayek S, Nemer M. Cardiac natriuretic peptides: from basic discovery to clinical practice. Cardiovascular Therapeutics. (2010) 1–15. 2010 Blackwell Publishing Ltd.
2000-2009
  • Koshiba-Takeuchi K, Mori AD, Kaynak BL, Cebra-Thomas J, Sukonnik T, Georges RO, Latham S, Beck L, Henkelman RM, Black BL, Olson EN, Wade J, Takeuchi JK, Nemer M, Gilbert SC, Bruneau BG. Reptilian heart development and the molecular basis of cardiac chamber evolution. Nature. 2009 Sept 3; 461(7260):95-8.
  • Kyrönlahti A, Rämö M, Tamminen M, Unkila-Kallio L, Butzow R, Leminen A, Nemer M, Rahman N, Huhtaniemi I, Heikinheimo M, Anttonen M. GATA-4 regulates Bcl-2 expression in ovarian granulosa cell tumors. Endocrinology, 2008 Nov, 149(11):5635-42
  • 1Georges R, 1Nemer G, Lefebvre C, Nemer M. Distinct expression and function of alternatively spliced Tbx5 isoforms in cell growth and differentiation. 1These authors contributed equally to the work. Mol Cell Biol 2008, 28(12):4052-4067
  • Rivard K, Paradis P, Nemer M, Fiset C. Cardiac-specific overexpression of the human type 1 angiotensin II receptor causes delayed repolarization. Cardiovasc Res, 2008, 78(1):53-62
  • Nemer M. Genetic insights into normal and abnormal heart development. J Cardiovasc Pathol, 2008, 17(1), 48-54
  • Majalahti T, Suo-Palosaari M, Sarman B, Hautala N, Pikkarainen S, Tokola H, Vuolteenaho O, Wang J, Paradis P, Nemer M, Ruskoaho H. Cardiac BNP gene activation by angiotensin II in vivo. Mol Cell Endocrinol, 2007, 273(1-2):59-67
  • Nemer M, Horb ME. A role for the KLF family of transcriptional regulators in cardiomyocyte proliferation and differentiation. Cell Cycle 2007, 6(2):117-121
  • 1Lavallée G, 1Andelfinger G, Nadeau M, Lefebvre C, Nemer G, Horb M, Nemer M. The Kruppel-like transcription factor KLF13 is a GATA-4 collaborator for heart development
  • EMBO J 2006, 25:5201-5213. 1These authors contributed equally to the work
  • Nemer G, Fadlalah F, Usta J, Nemer M, Dbaibo G, Obeid M, Bitar F. A novel mutation in the GATA4 gene in patients with tetralogy of Fallot. Hum Mutat 2006, 27(3):293-294
  • Wang J, Paradis P, Aries A, Komati H, Lefebvre C, Wang H, Nemer M. Convergence of PKC and JAK-STAT signaling on transcription factor GATA-4. Mol Cell Biol 2005, 25 (22), 9829-9844
  • Debrus S, Rahbani L, Marttila M, Delorme B, Paradis P, Nemer M. The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of a1-adrenergic signaling. Mol Cell Biol 2005, 25(19), 8669-8682
  • Morin S, Pozzulo G, Robitaille L, Cross J, Nemer M. MEF2-dependent recruitment of the HAND1 transcription factor results in synergistic activation of target promoters. J Biol Chem 2005, 280(37):32272-32278
  • Takeuchi JK, Koshiba-Takeuchi K, Mileikovskaia M, Mori AD, Arruda EP, Gertsenstein M, Georges R, Davidson L, Mo R, Hui CC, Henkelman RM, Nemer M, Black BL, Nagy A, Bruneau BG. Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motor neuron development. Development 2005, 132(10), 2463:2474
  • Temsah R, Nemer M. GATA factors and transcriptional regulation of cardiac natriuretic peptide genes. Regul Pept 2005, 128 (3), 177-185
  • Chandrasekar B, Mummidi SM, Claycomb WC, Mestril R, Nemer M. Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phophoinositide-dependent kinase-1-Akt-GATA4 signaling pathway in cardiomyocytes. J Biol Chem 2005, 280 (6):4553-4567
  • Davidson D, Shi X, Zhang S, Wang H, Nemer M, Ono N, Yanagi Y, Veillette A. Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in TH2 cytokine regulation. Immunity 2004, 21:707-717
  • Toro R, Saadi I, Kuburas A, Nemer M, Russo AF. Cell-specific activation of the atrial natriuretic factor promoter by PITX2 and MEF2A. J Biol Chem 2004, 279:52087-52094
  • Aries A, Paradis P, Lefebvre C, Schwartz RJ, Nemer M. Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity. Proc Nat Acad Sci USA, 2004, 101:6975-6980
  • Tong A, Lenihan D, Divakaran V, Tristan JM, Nemer M, Swafford J, Geisler G, Vooletich M, Handy B, Durand JB. B-type natriuretic peptide is a biochemical predictor of myocardial contractile reserve during dobutamine stress echocardiogram, J Am Coll Cardiol, March 2004, 43(5s1):A173-A173 doi: 10.1016/S0735-1097(04)90734-6
  • McBride K, Charron F, Lefebvre C, Nemer M. Interaction with GATA transcription factors provides a mechanism for cell-specific effects of c-Fos. Oncogene 2003,22:8403-8412
  • Pikkarainen S, Tokola H, Majalahti-Palviainen T, Kerkelä, Hautala N, Bhalla SS, Charron F, Nemer M, Vuolteenaho O, Ruskoaho H. GATA-4 is a nuclear mediator of mechanical stretch-activated hypertrophic program. J Biol Chem 2003, 278:23807-23816
  • Nemer G, Nemer M. Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and –6. Dev Biol 2003, 254:131-148
  • Brewer A, Nemer G, Gove C, Rawlins F, Nemer M, Patient R, Pizzey J. Widespread expression of an extended peptide sequence of GATA-6 during murine embryogenesis and non-equivalence of RNA and protein expression domains. Mech Dev 2003, 119 Suppl1:S121-129
  • Nemer G, Nemer M. Cooperative interaction between GATA-5 and NF-ATc regulates endothelial-endocardial differentiation of cardiogenic cells. Development 2002, 129:4045-4055
  • Suo M, Hautala N, Foldes G, Szokodi I, Toth M, Leskinen H, Uusimaa P, Vuolteenaho O, Nemer M, Ruskoaho H. Posttranscriptional Control of BNP Gene Expression in Angiotensin II-Induced Hypertension. Hypertension 2002, 39:803-8
  • Nemer G, Nemer M. Regulation of heart development and function through combinatorial interactions of transcription factors. Ann Med 2001, 33:604-610
  • Marttila M, Hautala N, Paradis, P, Toth M, Vuolteenaho O, Nemer M, Ruskoaho H. GATA-4 mediates activation of the B-type natriuretic peptide gene expression in response to hemodynamic stress. Endocrinology 2001, 142:4693-4700
  • Charron F, Tsimiklis G, Robitaille L, Arcand M, Meloche, S, Nemer M. Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes Dev 2001, 15:2702-2719
  • 1Bruneau BG, 1Nemer G, Schmitt, JP, Charron F, Robitaille L, Caron S, Conner DA, Gessler M, 2Nemer M, Seidman CE, 2Seidman JG. A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell 2001, 106:709-721. 1These authors contributed equally to the work. 2Co-senior authors.
  • McBride K, Nemer M. Regulation of the ANF and BNP promoters by GATA factors: lessons learned for cardiac transcription. Can J Physiol Pharmacol 2001, 79:673-681
  • Bhalla SS, Robitaille L, Nemer M. Cooperative activation by GATA-4 and YY1 of the cardiac B-type natriuretic peptide promoter. J Biol Chem 2001, 276:11439-11445
  • Morin S, Paradis P, Aries A, NemerM. SRF/GATA ternary complex required for nuclear signaling by a G-protein coupled receptor. Mol Cell Biol 2001, 21:1036-1044
  • Charron F, Morin S, Nemer M. Interactions entre les facteurs MEF2 et GATA dans la différenciation cellulaire. Médecine/sciences 2001, 17:98-102
  • Belaguli NS, Sepulveda JL, Nigam V, Charron F, Nemer M, Schwartz RJ. Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators. Mol Cell Biol 2000, 20:7550-7558
  • Fotheringham J, Xu FY, Nemer M, Kardami E, Choy PC, Hatch GM. Lysophosphatidylethanolamine acyltransferase activity is elevated during cardiac cell differentiation. Biochim Biophys Acta 2000, 1485:1-10
  • Morin S, Charron F, Robitaille L, Nemer M. GATA-4-dependent recruitment of the MEF2 proteins to target promoters. EMBO J, 2000, 19:2046-2055
  • Xu FY, Kardami E, Nemer M, Choy PC, Hatch GM. Elevation in phosphatidylethanolamine is an early but not essential event for cardiac cell differentiation. Exp Cell Res 2000, 256:358-364
  • Paradis P, Youcef-Dali N, Paradis FW, Thibault G, Nemer M. Overexpression of angiotensin II type 1 receptor in cardiomyocytes induces cardiac hypertrophy and remodeling. Proc Nat Acad Sci USA, 2000, 97:931-936
1990-99
  • Nemer G, Qureshi ST, Malo D, Nemer M. Functional analysis and chromosomal mapping of GATA5, a gene encoding a zinc finger DNA binding protein. Mamm Genome 1999, 10:993-999
  • Kuo HC, Ruiz-Lozano P, Zou Y, Nemer M, Chien KR. Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis. Development 1999, 126:4223-4234
  • Xu FY, Fandrich RR, Nemer M, Kardami E, Hatch GM. The subcellular distribution of protein kinase Ca, e and z isoforms during cardiac cell differentiation. Arch Biochem Biophys 1999, 367:17-25
  • Charron F, Nemer M. GATA transcription factors and cardiac development. Sem Cell & Dev Biol 1999, 10:85-91
  • Charron F, Paradis P, Bronchain O, Nemer G, Nemer M. Cooperative interaction between GATA-4 and GATA-6 regulates myocardial ANF gene expression. Mol Cell Biol 1999, 19:4355-4365
  • McBride K and Nemer M. The C-terminal domain of c-fos is required for activation of an AP-1 site specific for jun-fos heterodimers. Mol Cell Biol 1998, 18:5073-5081
  • Viger RS, Mertineit C, Trasler JM, Nemer M. Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the Müllerian inhibiting substance promoter. Development 1998, 125:2665-2675
  • Krosl G, He G, Lefrançois M, Charron F, Roméo PH, Jolicoeur P, Kirsch IR, Nemer M, Hoang T. Transcription factor SCL is required for c-kit expression and c-kit function in hemopoietic cells. J ExpMed 1998, 188(3):439-450
  • Sepulveda JL, Belaguli N, Nigam V, Chen CY, Nemer M, Schwartz RJ. GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression. Mol Cell Biol 1998, 18:3405-3415
  • Durocher D, Nemer M. Combinatorial interactions regulating cardiac transcription. Dev Genet 1998, 22:250-262
  • Durocher D, Charron F, Warren R, Schwartz RJ, Nemer M. The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors.EMBO J.1997, 16:5687-5696
  • Grépin C, Nemer G, Nemer M. Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor. Development 1997, 124 (12), 2387-2395
  • Qureshi ST, Bronchain O, Nemer M, Malo D. Mapping of the GATA-6 gene to mouse chromosome 18. Mamm Genome 1996, 7:705-706
  • Durocher D, Chen CY, Ardati A, Schwartz RJ, Nemer M. The ANF promoter is a downstream target for Nkx-2.5 in the myocardium. Mol Cell Biol 1996, 16:4648-4655
  • Sebastiani G, Grépin C, Nemer M, Malo D. The mouse Gata4 transcription factor maps to chromosome 14. Mamm Genome 1995, 6:442-445
  • Grépin C, Robitaille L, Antakly T, Nemer M. Inhibition of transcription factor GATA-4 expression blocks in vitro cardiac muscle differentiation. Mol Cell Biol 1995, 15:4095-4102
  • Arden KC, Viars CS, Weiss S, Argentin S, Nemer M. Localization of the human B-type natriuretic peptide precursor (NPPB) gene to chromosome 1p36. Genomics 1995, 26:385-389
  • Grépin C, Durocher D, Nemer M. Le coeur : un programme unique de transcription et de différenciation musculaire. Médecine/Sciences 1995, 11:395-405
  • Sebastiani G, Durocher D, Gros P, Nemer M, Malo D. Localization of the Catf1 transcription factor gene to mouse Chromosome 19. Mamm Genome 1995, 6:147-148
  • Gerbes AL, Dagnino L, Nguyen T, Nemer M. Transcription of BNP and ANP genes in human tissues. J Clin Endocrinol Metab 1994, 78:1307-1311
  • Grépin C, Dagnino L, Robitaille L, Haberstroh L, Antakly T, Nemer M. A hormone coding gene identifies a pathway for cardiac but not skeletal muscle gene transcription. Mol Cell Biol 1994, 14:3115-3129
  • Burns K, Duggan B, Atkinson EA, Famulski KS, Nemer M, Bleackley RC, Michalak M. Modulation of gene expression by calreticulin binding to glucocorticoid receptor. Nature 1994, 367, 476-480
  • Argentin S, Ardati A, Tremblay S, Lihrmann I, Robitaille L, Drouin J, Nemer M. Developmental stage-specific regulation of ANF gene transcription in cardiac cells. Mol Cell Biol 1994, 14:777-790
  • Ardati A, Nemer M. A nuclear pathway for a1–adrenergic receptor signaling in cardiac cells. EMBO J 1993, 12:5131-5139
  • Gerbes AL, Nemer M. Detection of C-type natriuretic peptide compared with brain and atrial natriuretic peptide transcripts in human heart by the polymerase chain reaction. Clin Investig 1993, 71:672
  • Vollmar AM, Gerbes AL, Nemer M, Schulz R. Detection of c-type natriuretic peptide (CNP) transcript in the rat heart and immune organs. Endocrinol 1993, 132:1872-1874
  • Gutkowska J, Tremblay J, Antakly T, Meyer R, Mukaddam-Daher S, Nemer M. The atrial natriuretic peptide system in rat ovaries. Endocrinol 1993, 132:693-700
  • Drouin J, Sun YL, Chamberland M, Gauthier Y, De Léan A, Nemer M, Schmidt TJ. Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene. EMBO J 1993, 12:145-156
  • McBride K, Robitaille L, Tremblay S, Argentin S, Nemer M. Fos/jun repression of cardiac-specific transcription in quiescent and growth-stimulated myocytes is targeted at a tissue-specific cis element. Mol Cell Biol 1993, 13:600-612
  • Dagnino L, Lavigne J-P, Nemer M. Increased transcripts for B-type natriuretic peptide in spontaneously hypertensive rats. Quantitative polymerase chain reaction for atrial and brain natriuretic peptide transcripts. Hypertension 1992, 20:690-700
  • Drouin J, Sun YL, Tremblay S, Lavender P, Schmidt TJ, De Léan A, NemerM. Homodimer formation is rate-limiting for high affinity DNA binding by glucocorticoid receptor. Mol Endocrinol 1992, 6:1299-1309
  • Argentin S, Sun YL, Lihrmann I, Schmidt T, Drouin J, Nemer M. Distal cis-acting promoter sequences mediate glucocorticoid stimulation of cardiac atrial natriuretic factor gene transcription. J Biol Chem 1991, 266:23315-23322
  • Gutkowska J, Tremblay J, Meyer R, Marcinkiewicz M, Nemer M. Evidence for atrial natriuretic peptide (ANP) synthesis and the presence of ANP-transducing receptors in the rat olfactory bulb. J Neurochem 1991, 57:1855-1861
  • Dagnino L, Drouin J, Nemer M. Differential expression of natriuretic peptide genes in cardiac and extracardiac tissues. Mol Endocrinol 1991, 5:1292-1300
  • Debinski W, Kuchel O, Buu NT, NemerM, Tremblay T, Hamet P. Effect of prolonged high salt diet on atrial natriuretic factor in rats. Proc Soc Exp Biol Med 1990, 194:251-257
  • Drouin J, Sun YL, NemerM. Regulatory elements of the pro-opiomelanocortin gene. Pituitary specificity and glucocorticoid repression. Trends Endocrinol Metab 1990; 1:219-225
1980-89
  • Drouin J, Sun YL, Nemer M. Glucocorticoid repression of pro-opiomelanocortin gene transcription. J Steroid Biochem 1989, 34:63-69
  • Drouin J, NemerM, Charron J, Gagner JP, Jeannotte L, Sun YL, Therrien M, Tremblay Y. Tissue-specific activity of the pro-opiomelanocortin (POMC) gene and repression by glucocorticoids. Genome 1989, 31:510-519
  • Gutkowska J, NemerM. Structure, expression, and function of atrial natriuretic factor in extraatrial tissues. Endocrine Rev 1989, 10:519-536
  • Drouin J, Trifiro MA, Plante RK, Nemer M, Eriksson P, Wrange Ö. Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription. Mol Cell Biol 1989, 9:5305-5314
  • Thibault G, Nemer M, Drouin J, Lavigne JP, Ding J, Charbonneau C, Garcia R, Genest J, Jasmin G, Sole MJ, Cantin M. Ventricles as a major site of atrial natriuretic factor synthesis and release in cardiomyopathic hamsters with heart failure. Circ Res 1989, 65:71-82
  • Cantin M, Thibault G, Haile-Meskel H, Ding J, Milne RW, Ballak M, Charbonneau C, Nemer M, Drouin J, Garcia R, Genest J. Atrial natriuretic factor in the impulse-conduction system of rat cardiac ventricles. Cell Tissue Res 1989, 256:309-325
  • Gutkowska J, Nemer M, Sole MJ, Drouin J, Sirois P. Lung is an important source of atrial natriuretic factor in experimental cardiomyopathy. J Clin Invest 1989, 83:1500-1504
  • Cantin M, Thibault G, Haile-Meskel H, Ding J, Nemer M, Drouin J, Garcia R, Genest J. Atrial natriuretic factor in the impulse conduction system of the heart. Trans Ass Am Phys 1988, C1:100-113
  • Lavigne JP, Drouin J, Ding J, Thibault G, NemerM, Cantin M. Atrial natriuretic factor (ANF) gene expression in the Brattleboro rat. Peptides 1988, 9:817-824
  • Debinski W, Kuchel O, Nemer M, Buu NT, Genest J. Atrial natriuretic factor in sympathetic ganglia of the rat: dependence on cholinergic innervation. Neuroscience 1988, 27:965-968
  • Galipeau J, NemerM, Drouin J. Ventricular activation of the atrial natriuretic factor gene in acute myocardial infarction. New Engl J Med 1988, 319:654-655
  • Drouin J, Lavigne JP, NemerM. Expression du gène du facteur natriurétique des oreillettes: un marqueur de l'hypertrophie ventriculaire. Union Méd Can 1988, 117:64-67
  • Nemer M, Sirois D, Drouin J. TaqI polymorphism at the 3' end of the human pronatriodilatin gene (hPND). Nucleic Acids Res 1986, 14:8697
  • Nemer M, Antakly T, Argentin S, Lavigne JP, Drouin J. Cloning and expression of the atrial natriuretic factor gene. Clin PhysBiochem 1988, 6:163-170
  • Drouin J, Charron J, Gagner JP, Jeannotte L, Nemer M, Plante RK, Wrange Ö. Pro-opiomelanocortin: a model for negative regulation of transcription by glucocorticoids. J Cell Biochem 1987, 35:293-304
  • Argentin S, Drouin J, Nemer M. Thyroid hormone stimulates pro-natriodilatin mRNA levels in primary cardiocyte cultures. Biochem Biophys Res Comm 1987, 146:1336-1341
  • Nemer M, Sirois D, Drouin J. XhoI polymorphism at the human pronatriodilatin (hPND) gene locus. NucleicAcidsRes 1986, 14:8696
  • Nemer M, Lavigne JP, Drouin J, Thibault G, Gannon M, Antakly T. Expression of atrial natriuretic factor gene in heart ventricular tissue. Peptides 1986, 7:1147-1152
  • NemerM, Thériault NY, Schifman AL, Ogilvie KK. Synthesis and properties of symmetrically linked diribonucleotides. Nucleosides Nucleotides 1985, 4:257-258
  • Yang-Feng TL, Floyd-Smith G, Nemer M, Drouin J, Franke U. The pronatriodilatin gene is located on the distal short arm of human chromosome 1 and on mouse chromosome 4. Am J Hum Genet 1985, 37:1117-1128
  • Argentin S, Nemer M, Drouin J, Scott G, Kennedy K, Davies P. The gene for rat atrial natriuretic factor. J Biol Chem 1985, 260:4568-4571
  • Drouin J, Chamberland M, Charron J, Jeannotte L, Nemer M. Structure of the rat pro-opiomelanocortin (POMC) gene. FEBSLetter 1985, 193:54-58
  • Nemer M, Chamberland M, Sirois M, Argentin S, Drouin J, Dixon RA, Zivin RA. Condra JA. Gene structure of human cardiac hormone precursor, pronatriodilatin. Nature 1984, 312:654-656
  • Zivin RA, Condra JH, Dixon RA, Seidah NG, Chrétien M, Nemer M, Chamberland M, Drouin J. Molecular cloning and characterization of DNA sequences encoding rat and human atrial natriuretic factors. Proc Natl Acad Sci USA 1984, 81:6325-6329
  • Ogilvie KK, Nemer M, Gillen MF. Large scale bench-top synthesis of a nineteen unit ribonucleotide on silica gel. TetrahedronLett 1984, 25:1669-1672
  • Beavis R, Ens W, NemerM, Ogilvie KK, Standing KG, Westmore JB. Secondary ion mass spectrometry of protected oligonucleotides. Int J Mass Spectrom Ion Phys 1983, 46:475-478
  • Ogilvie KK, NemerM, Hakimelahi GH, Proba ZA, Lucas M. N-levulination of nucleosides. Tetrahedron Lett 1982, 23:2615-2618
  • Ens W, Standing KG, Westmore JB, Ogilvie KK, NemerM. Secondary ion mass spectrometry of protected diribonucleoside monophospahtes with a time-of-flight mass spectrometer. AnalChem 1982, 54:960-966
  • McNeal CJ, Ogilvie KK, Thériault NY, NemerM. A new method for sequencing fully protected oligonucleotides using 252CF plasma desorption mass spectrometry. 3. Positive ions. J Am Chem Soc 1982, 104:981-984
  • McNeal CJ, Ogilvie KK, Thériault NY, NemerM. A new method for sequencing fully protected oligonucleotides using 252CF plasma desorption mass spectrometry. 2. Negative ions of subunits in the stepwise synthesis of a Heptaribonucleotide. J Am Chem Soc 1982, 104:976-980
  • McNeal CJ, Ogilvie KK, Thériault NY, NemerM. A new method for sequencing fully protected oligonucleotides using 252CF–plasma desorption mass spectrometry. I. Negative ions of dinucleoside monophosphates. J Am Chem Soc 1982, 104:972-975
  • Ogilvie KK, NemerM. Nonaqueous oxidation of phosphites to phosphates in nucleotide synthesis. Tetrahedron Lett 1981, 22:2531-2532
  • Ogilvie KK, NemerM. Silica gel as solid support in the synthesis of oligoribonucleotides. Tetrahedron Lett 1980, 21:4159-4162
  • Nemer M, Ogilvie KK. Phosphoramidate analogues of diribonucleoside monophosphates. Tetrahedron Lett 1980, 21:4153-4154
  • NemerM, Ogilvie KK. Ribunucleotide analogues having novel internucleotide linkages. Tetrahedron Lett 1980, 21:4149-4152
  • Ogilvie KK, NemerM. The synthesis of phosphite analogues of ribonucleotides. Tetrahedron Lett 1980, 21:4145-4148
  • Ogilvie KK, NemerM, Thériault N, Pon R, Seifert JM. A complete procedure for the chemical synthesis of oligoribonucleotides. Nucl Acids Res Symposium Series 1980, 7:147-150
  • Ogilvie KK, Thériault NY, Seifert JM, Pon RT, NemerM. The synthesis of oligoribonucleotides IX. A comparison of protecting groups in the dichloridite procedure. Can J Chem 1980, 58:2686-2693
  • Ogilvie KK, NemerM. The synthesis of oligoribonucleotides VI. The synthesis of a hexadecamer by a block condensation approach. Can J Chem 1980, 58:1389-1397

Book Chapters

  • Yamak A, Nemer M. The role of embryonic and differentiated cells in cardiac development. Biomaterials-based Cardiac Regeneration, Springer International Publishing, AG Switzerland. Suuronen, Erik J., Ruel, Marc (Eds.), 2015, XV, 323 p. 47 illus., 45 illus. in color.
  • Nemer M, Nemer G.  GATA4 in Heart Development and Disease. In Heart Development and Regeneration, 2nd Ed, edited by N Rosenthal and R Harvey. Academic Press. 2010, Volume 2, p. 599-616
  • Hariri F, Nemer G, Nemer M.  The GATA family of zinc finger transcription factors: in Focus on zinc finger protein research, Research Signpost.  K Yoshida, Editor, Research Signpost, Publisher 2009, 161-184
  • Nemer M, Dali-Youcef N, Wang H, Aries A, Paradis P.  Mechanisms of angiotensin II-dependent progression to heart failure.  2006 Heart failure:  molecules, mechanisms and therapeutic targets.  John Wiley & Sons Ltd, Chichester UK (Novartis Foundation Symposium 274) p 58-72
  • Charron F, Nemer M.  Cardiac development and regulation of cardiac transcription.  In Heart Physiology and Pathophysiology, 4th Ed, Part VIII, Developmental changes and aging, edited by Sperelakis et al., Academic Press.  2001, 705-717
  • Durocher D, Grépin C, Nemer M.  Regulation of gene expression in the endocrine heart.  In :  Recent Progress in Hormone Research, PM Conn, Ed (The Endocrine Society Press) 1998, 53:7-23
  • Nemer M.  Gata factors in cardiac development. In:  Part II – Transcription factors in cardiac myogenesis and morphogenesis.  Workshop III - Genetic control of heart development. Harvey RP, Olson EN, Schulz RA, Altman JS, eds.  HFSP 1997, 84-91.
  • Drouin J, NemerM, Sun YL, Therrien M.  Cell specificity in the control of the POMC gene expression. In: Fidia Research Foundation, Neurosteroids and Brain Function, Costa E and Paul SM Eds, 1991, 8:37-40
  • Cantin M, Thibault F, Anand-Srivastava MB, Haile-Meskel H, Nemer M, Drouin J, Garcia R, Genest J.  ANF in cardiac ventricles and conduction system.  In: Proc 8th International Congress of Endocrinology, The whole heart is an endocrine gland. Imura H and Matsuo H, Eds, 1991:17-40
  • Gutkowska J, Nemer M, Marcinkiewicz M, Lavigne JP, Sole M, Drouin J, Sirois P.  Atrial natriuretic factor in extra-atrial tissues:  expression in lungs and olfactory mucosa. In: Proc 3rd International Conference on Diuretics, JB Puschett and A Greenberg, Eds, 1990:543-551
  • Drouin J, Therrien M, Sun YL, Mullick A, Nemer M.  Cell specificity and glucocorticoid repression of POMC gene transcription.  In: New leads in opioid research, International congress series 914, JM Van Ree, AH Mulder, VM Wiegant, TB Greidanus ed, Excerpta Medica 1990, S.3.1:109-110
  • Drouin J, Nemer M, Sun YL, Therrien M, Wrange Ö. Glucocorticoid repression of the pro-opiomelanocortin (POMC) gene.  In: ACTH, Cushing's Syndrome, and other hypercortisolemic states, D Lüdecke ed, 1990, 5:27-39
  • Cantin M, Thibault G, Anand-Srivastava MB, Haile-Meskel H, Garcia R, Hamet P, Larochelle P, Nemer M, Drouin J, Genest J.  Pathophysiological effects and role of ANF.  In: Progress in Endocrinology, H Imura et al., eds, VIIIth International Excerpta Medica, VIIIth Congress of Endocrinology, Kyoto JAPON, 1988, 1:185-192
  • Genest J, Cantin M, Larochelle P, Nemer M. Frontiers in biologically active atrial peptides.  In: Brenner BM, Laragh JH eds.  Advances in Atrial Peptide Research, Vol II: American Society of Hypertension Symposium Series, Chap 1, Press, New York, 1988, 1-8
  • Gutkowska J, Nemer M. ANF in extra-atrial tissues.  In: Genest J and Cantin M eds.  The Atrial Natriuretic Factor: Its Physiology and Biochemistry, Chap 5, Springer-Verlag, Heidelberg, Rev Physiol Biochem Pharmacol 1988, 110:25-30
  • Nemer M. Molecular Biology of ANF.  In: Genest J, Cantin M eds.  The Atrial Natriuretic Factor:  Its Physiology and Biochemistry, Chap 3, Springer-Verlag, Heidelberg, Rev Physiol Biochem Pharmacol 1988, 110:15-19

News and Views

  • Nemer M.  GATA-4:  an integrator of hormonal and growth factor signaling in the heart.  CSBMB/SCBBMC Bulletin 2001, pp. 77-81
  • Grépin C, Nemer M.  Facteurs bHLH et morphogenèse cardiaque.  médecine/sciences 1996, 12:515-516
  • Durocher D, Nemer M.  Rôle anti-arythmogène de l'endothéline dans l'ischémie cardiaque.  médecine/sciences 1995, 11: 291
  • Durocher D, Nemer M.  Rétinoïdes et bases moléculaires des malformations cardiaques congénitales.  médecine/sciences 1995, 11:132
  • Nemer M.  Réévaluation du rôle de TGFb1 dans le développement cardiaque.  médecine/sciences 1994 10:1161-1162

Text Interviews

  • Training Tomorrow’s Leaders (Biovision), International Innovation, March 2015
  • Cancer durg toxic to the heart study says – Imatinib could cause cardiac stress and dysfunction. Ottawa Citizen. Feb 15 2014
  • Online Scavenger hunt to showcase university research projects. Ottawa Citizen. Jan 29 2014
  • Fonds pour la recherche. Le Droit. Apr 23 2012
  • Chaires de recherche. Le Droit. Mar 13 2012
  • University research funding cuts by the province. Ottawa Citizen. Jan 11 2012
  • Career in physics. Ottawa Citizen. May 31 2010
  • Gender Representation. Vancouver Sun. May 28 2010
  • 3% du PIB pour la recherche scientifique. Le Droit, May 15 2010
  • Projets de recherche scientifique. Le Droit. Nov 11 2009
  • La science en français. Le Droit. May 10 2009
  • La science en français, une affaire capitale! Cahier spécial de l’Acfas du Le Devoir. Apr 23 2009. Reporter Martine Letarte

Broadcast Interviews

  • Gene research related to heart health, CBC Radio, July 2014
  • Les visionnaires. Série télévisé Les Visionnaires – Radio Canada. Aug 15 2012
  • Recherches et innovations au Canada. TV Ontario (TVO). May 12 2009
  • La science en français, une affaire capitale! Émission d’affaires publiques l’Ontario – Radio Canada. May 9 2009. Émission provinciale ontarienne animée par Benoit Cantin

Abstracts

263

Back to top